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APC

Tumor Suppressor
Also known as PPP1R46, DP2.5
APC, a tumor suppressor involved in WNT signaling, is recurrently altered in colorectal cancer.
Show APC background
NCBI Gene324
Ensembl GeneENSG00000134982 (GRCh37/GRCh38)
Location
Chr5:112043195-112181936 (GRCh37)
Chr5:112707498-112846239 (GRCh38)
Ensembl TranscriptENST00000257430 (GRCh37/GRCh38)
RefSeqNM_000038.5 (GRCh37/GRCh38)
Annotated Mutations in MSK-IMPACT™ Clinical Sequencing Cohort (Zehir et al., Nat Med 2017)
A list of the oncogenic and mutation effects of all OncoKB™ curated APC alterations.
If you notice any mistakes or omissions, please reach out to us.
Alteration
Oncogenic
Mutation Effect
Description
Deletion
Likely Oncogenic
Likely Loss-of-function
Truncating Mutations
Likely Oncogenic
Likely Loss-of-function
R640G
Oncogenic
Loss-of-function
N1026S
Likely Oncogenic
Loss-of-function
I1307K
Inconclusive
Inconclusive
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