Levels of Evidence
Actionable Genes
Oncology Therapies
CDx
Cancer Genes
API / License
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FAQ
DNMT3A
Tumor Suppressor
Highest level of evidence:
Level Dx2
DNMT3A, a tumor suppressor and DNA methyltransferase, is recurrently mutated in acute myeloid leukemia and other hematologic malignancies
Show DNMT3A background
NCBI Gene
1788
Ensembl Gene
ENSG00000119772 (
GRCh37
/
GRCh38
)
Location
Chr2:25455845-25565459 (GRCh37)
Chr2:25227855-25342590 (GRCh38)
Ensembl Transcript
ENST00000264709 (
GRCh37
/
GRCh38
)
RefSeq
NM_022552.4 (
GRCh37
/
GRCh38
)
Annotated Mutations in
MSK-IMPACT™ Clinical Sequencing Cohort
(
Zehir et al., Nat Med 2017
)
195 Oncogenic
61 Neutral
4 Inconclusive
...
Annotated Alterations
Diagnostic
A list of diagnostic DNMT3A alterations and the corresponding
OncoKB™ diagnostic level of evidence
. Diagnostic implications are curated for hematologic malignancies only.
If you notice any mistakes or omissions, please reach out to us.
Level
Alterations
Level-associated cancer types
Citations
Oncogenic Mutations
Myelodysplastic Syndromes
1
Oncogenic Mutations
Angioimmunoblastic T-Cell Lymphoma
1
Oncogenic Mutations
Early T-Cell Precursor Lymphoblastic Leukemia
1
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