Levels of Evidence
Actionable Genes
Oncology Therapies
CDx
Cancer Genes
API / License
About
News
FAQ
ERBB3
Oncogene
Also known as LCCS2, HER3
ERBB3, a receptor tyrosine kinase, is altered by mutation or amplification in various cancer types.
Show ERBB3 background
NCBI Gene
2065
Ensembl Gene
ENSG00000065361 (
GRCh37
/
GRCh38
)
Location
Chr12:56473641-56497289 (GRCh37)
Chr12:56076799-56103505 (GRCh38)
Ensembl Transcript
ENST00000267101 (
GRCh37
/
GRCh38
)
RefSeq
NM_001982.3 (
GRCh37
/
GRCh38
)
Annotated Mutations in
MSK-IMPACT™ Clinical Sequencing Cohort
(
Zehir et al., Nat Med 2017
)
18 Oncogenic
2 Neutral
3 Inconclusive
...
Annotated Alterations
A list of the oncogenic and mutation effects of
all OncoKB™ curated
ERBB3 alterations.
If you notice any mistakes or omissions, please reach out to us.
Alteration
Oncogenic
Mutation Effect
Description
Amplification
Oncogenic
Gain-of-function
M91I
Likely Oncogenic
Likely Gain-of-function
R103G
Inconclusive
Inconclusive
V104L
Likely Oncogenic
Likely Gain-of-function
V104M
Oncogenic
Gain-of-function
N126K
Likely Oncogenic
Likely Gain-of-function
A232T
Likely Oncogenic
Likely Gain-of-function
A232V
Oncogenic
Gain-of-function
P262H
Oncogenic
Gain-of-function
G284R
Oncogenic
Gain-of-function
D297H
Likely Oncogenic
Likely Gain-of-function
D297Y
Likely Oncogenic
Likely Gain-of-function
K329E
Likely Oncogenic
Likely Gain-of-function
K329T
Likely Neutral
Likely Neutral
T355I
Likely Oncogenic
Likely Gain-of-function
T389K
Oncogenic
Gain-of-function
R475W
Likely Oncogenic
Likely Gain-of-function
R669C
Inconclusive
Inconclusive
V714M
Likely Neutral
Likely Neutral
Q809R
Oncogenic
Gain-of-function
S846I
Oncogenic
Gain-of-function
E928G
Oncogenic
Gain-of-function
A1131T
Inconclusive
Inconclusive
Loading...
You must enable javascript to view this page.