ERBB3

Oncogene

Also known as LCCS2, HER3

ERBB3, a receptor tyrosine kinase, is altered by mutation or amplification in various cancer types.

Show ERBB3 background

NCBI Gene	2065
Ensembl Gene	ENSG00000065361 (GRCh37/GRCh38)
Location	Chr12:56473641-56497289 (GRCh37) Chr12:56076799-56103505 (GRCh38)
Ensembl Transcript	ENST00000267101 (GRCh37/GRCh38)
RefSeq	NM_001982.3 (GRCh37/GRCh38)

Annotated Mutations in MSK-IMPACT™ Clinical Sequencing Cohort (Zehir et al., Nat Med 2017)

A list of the oncogenic and mutation effects of all OncoKB™ curated ERBB3 alterations.

If you notice any mistakes or omissions, please reach out to us.

Amplification

Oncogenic

Gain-of-function

M91I

Likely Oncogenic

Likely Gain-of-function

R103G

Inconclusive

V104L

Likely Oncogenic

Likely Gain-of-function

V104M

Oncogenic

Gain-of-function

N126K

Likely Oncogenic

Likely Gain-of-function

A232T

Likely Oncogenic

Likely Gain-of-function

A232V

Oncogenic

Gain-of-function

P262H

Oncogenic

Gain-of-function

G284R

Oncogenic

Gain-of-function

D297H

Likely Oncogenic

Likely Gain-of-function

D297Y

Likely Oncogenic

Likely Gain-of-function

K329E

Likely Oncogenic

Likely Gain-of-function

K329T

Likely Neutral

T355I

Likely Oncogenic

Likely Gain-of-function

T389K

Oncogenic

Gain-of-function

R475W

Likely Oncogenic

Likely Gain-of-function

R669C

Inconclusive

V714M

Likely Neutral

Q809R

Oncogenic

Gain-of-function

S846I

Oncogenic

Gain-of-function

E928G

Oncogenic

Gain-of-function

A1131T

Inconclusive