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Actionable Genes
Oncology Therapies
CDx
Cancer Genes
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MERTK
Oncogene
Also known as RP38, c-Eyk, Tyro12, mer
MERTK, a transmembrane tyrosine kinase, is infrequently altered in cancer.
Show MERTK background
NCBI Gene
10461
Ensembl Gene
ENSG00000153208 (
GRCh37
/
GRCh38
)
Location
Chr2:112656056-112787138 (GRCh37)
Chr2:111898607-112029561 (GRCh38)
Ensembl Transcript
ENST00000295408 (
GRCh37
/
GRCh38
)
RefSeq
NM_006343.2 (
GRCh37
/
GRCh38
)
...
Annotated Alterations
A list of the oncogenic and mutation effects of
all OncoKB™ curated
MERTK alterations.
If you notice any mistakes or omissions, please reach out to us.
Alteration
Oncogenic
Mutation Effect
Description
Amplification
Likely Oncogenic
Likely Gain-of-function
Y754F
Likely Neutral
Likely Loss-of-function
R758C
Likely Oncogenic
Likely Gain-of-function
R758H
Likely Oncogenic
Likely Gain-of-function
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