MTOR

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Oncogene

Highest level of evidence:Level 3A

Also known as FRAP1, RAFT1, FRAP2, FRAP, FLJ44809, RAPT1

MTOR, an intracellular kinase that regulates cell growth and metabolism, is infrequently mutated in various cancer types.

Show MTOR background

NCBI Gene	2475
Ensembl Gene	ENSG00000198793 (GRCh37/GRCh38)
Location	Chr1:11166592-11322564 (GRCh37) Chr1:11106535-11262551 (GRCh38)
Ensembl Transcript	ENST00000361445 (GRCh37/GRCh38)
RefSeq	NM_004958.3 (GRCh37/GRCh38)

Annotated Mutations in MSK-IMPACT™ Clinical Sequencing Cohort (Zehir et al., Nat Med 2017)

A list of the cancer type-specific MTOR alterations that may predict response to a targeted drug and the corresponding OncoKB™ level of evidence assigning their level of clinical actionability.

If you notice any mistakes or omissions, please reach out to us.