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Cancer Genes
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RAD51
Tumor Suppressor
Also known as RAD51A, RECA, HsRad51, FANCR, HsT16930, BRCC5
RAD51 encodes a protein involved in DNA double-strand break repair. Germline mutations or overexpression of RAD51 are associated with an increased risk of developing breast cancer.
Show RAD51 background
NCBI Gene
5888
Ensembl Gene
ENSG00000051180 (
GRCh37
/
GRCh38
)
Location
Chr15:40986972-41024354 (GRCh37)
Chr15:40694774-40732340 (GRCh38)
Ensembl Transcript
ENST00000267868 (
GRCh37
/
GRCh38
)
RefSeq
NM_002875.4 (
GRCh37
/
GRCh38
)
Annotated Mutations in
MSK-IMPACT™ Clinical Sequencing Cohort
(
Zehir et al., Nat Med 2017
)
1 Oncogenic
Cancer Types with RAD51 Mutations
Thyroid Cancer
Melanoma
% altered
0.10
0.20
0.30
0.40
...
Annotated Alterations
A list of the oncogenic and mutation effects of
all OncoKB™ curated
RAD51 alterations.
If you notice any mistakes or omissions, please reach out to us.
Alteration
Oncogenic
Mutation Effect
Description
Truncating Mutations
Likely Oncogenic
Likely Loss-of-function
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