RAD51

Tumor Suppressor
Also known as RAD51A, RECA, HsRad51, FANCR, HsT16930, BRCC5
RAD51 encodes a protein involved in DNA double-strand break repair. Germline mutations or overexpression of RAD51 are associated with an increased risk of developing breast cancer.
Show RAD51 background
NCBI Gene5888
Ensembl GeneENSG00000051180 (GRCh37/GRCh38)
Location
Chr15:40986972-41024354 (GRCh37)
Chr15:40694774-40732340 (GRCh38)
Ensembl TranscriptENST00000267868 (GRCh37/GRCh38)
RefSeqNM_002875.4 (GRCh37/GRCh38)
Annotated Mutations in MSK-IMPACT™ Clinical Sequencing Cohort (Zehir et al., Nat Med 2017)
Cancer Types with RAD51 Mutations
Thyroid CancerMelanoma% altered0.100.200.300.40
A list of the oncogenic and mutation effects of all OncoKB™ curated RAD51 alterations.
If you notice any mistakes or omissions, please reach out to us.
Alteration
Oncogenic
Mutation Effect
Description
Truncating Mutations
Likely Oncogenic
Likely Loss-of-function
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